Research

Our pediatric oncology studies are underway … meanwhile, feel free to explore our previous publications!

2026

Daratumumab in high-risk MGUS and low-risk smoldering myeloma: results of the Phase II D-PRISM study

Omar Nadeem, Michelle P. Aranha, Robert A. Redd, Michael Koontz, Jeffrey V. Matous, …, Paul G. Richardson, Gad Getz, Lorenzo Trippa, Romanos Sklavenitis-Pistofidis, Irene M. Ghobrial

Nature Communications · 08 Apr 2026 · doi:10.1038/s41467-026-71483-z

Enhanced dynamic risk stratification of smoldering multiple myeloma

Floris Chabrun, Daniel E. Schwartz, Susanna Gentile, Elias K. Mai, Tulika R. Gupta, …, Efstathios Kastritis, Meletios A. Dimopoulos, Marc S. Raab, Lorenzo Trippa, Irene M. Ghobrial

Nature Medicine · 24 Mar 2026 · doi:10.1038/s41591-026-04304-x

At a crossroads: circulating tumor cells in myeloma

Jean-Baptiste Alberge

Blood · 26 Feb 2026 · doi:10.1182/blood.2025032333

2025

Numbat-multiome: inferring copy number variations by combining RNA and chromatin accessibility information from single-cell data

Ruitong Li, Jean-Baptiste Alberge, Tina Keshavarzian, Junko Tsuji, Johan Gustafsson, …, Mathieu Lupien, Irene Ghobrial, Erin Parry, Teng Gao, Gad Getz

Briefings in Bioinformatics · 31 Aug 2025 · doi:10.1093/bib/bbaf516

SWIFT-seq enables comprehensive single-cell transcriptomic profiling of circulating tumor cells in multiple myeloma and its precursors

Elizabeth D. Lightbody, Romanos Sklavenitis-Pistofidis, Ting Wu, Junko Tsuji, Danielle T. Firer, …, Annie Cowan, John E. Ready, Catherine R. Marinac, Gad Getz, Irene M. Ghobrial

Nature Cancer · 08 Aug 2025 · doi:10.1038/s43018-025-01006-0

Large-scale dependency and drug screens to characterize the therapeutic vulnerabilities of multiple myeloma with 1q+

Romanos Sklavenitis-Pistofidis, Elizabeth D. Lightbody, Mairead Reidy, Junko Tsuji, Jean-Baptiste Alberge, …, Matthew S. Davids, Maria Papaioannou, Gad Getz, Irene M. Ghobrial, Salomon Manier

Blood · 03 Jul 2025 · doi:10.1182/blood.2024025102

Genomic landscape of multiple myeloma and its precursor conditions

Jean-Baptiste Alberge, Ankit K. Dutta, Andrea Poletti, Tim H. H. Coorens, Elizabeth D. Lightbody, …, Julian Hess, Romanos Sklavenitis-Pistofidis, Chip Stewart, Gad Getz, Irene M. Ghobrial

Nature Genetics · 21 May 2025 · doi:10.1038/s41588-025-02196-0

SVelfie: A method for discovering cancer drivers based on enrichment of likely functional structural variants

Xavi Loinaz, Johnathan Dagan, Jean-Baptiste Alberge, Antonia Kowalewski, Mendy Miller, Julian M. Hess, Esther Rheinbay, Chip Stewart, Gad Getz

openRxiv · 10 Mar 2025 · doi:10.1101/2025.03.09.642284

Serum free light chains in a racially diverse population including African Americans and populations from South Africa

Luca Bertamini, Jean-Baptiste Alberge, David J. Lee, Habib El-Khoury, Sungjae Kim, …, Lorenzo Trippa, Catherine R. Marinac, Wenlong C. Chen, Maureen Joffe, Irene M. Ghobrial

Blood · 20 Feb 2025 · doi:10.1182/blood.2024026078

Deeper response predicts better outcomes in high-risk-smoldering-myeloma: results of the I-PRISM phase II clinical trial

Omar Nadeem, Michelle P. Aranha, Robert Redd, Michael Timonian, Sophie Magidson, …, Gad Getz, Lorenzo Trippa, Paul G. Richardson, Romanos Sklavenitis-Pistofidis, Irene M. Ghobrial

Nature Communications · 03 Jan 2025 · doi:10.1038/s41467-024-55308-5

2024

New horizons in our understanding of precursor multiple myeloma and early interception

David M. Cordas dos Santos, Rosa Toenges, Luca Bertamini, Jean-Baptiste Alberge, Irene M. Ghobrial

Nature Reviews Cancer · 16 Oct 2024 · doi:10.1038/s41568-024-00755-x

Inhibition of MICA and MICB shedding enhances memory-like NK-cell–mediated cytotoxicity against multiple myeloma

Sabrin Tahri, Sara Piccinelli, Nang Kham Su, Luisa Lampe, Han Dong, …, Pieter Sonneveld, Tom Cupedo, Kai W. Wucherpfennig, Irene M. Ghobrial, Rizwan Romee

Blood Advances · 11 Oct 2024 · doi:10.1182/bloodadvances.2023010869

Selective Enhancer Gain-of-Function Deregulates i MYC i Expression in Multiple Myeloma

Selective Enhancer Gain-of-Function Deregulates MYC Expression in Multiple Myeloma

Mahshid Rahmat, Kendell Clement, Jean-Baptiste Alberge, Romanos Sklavenitis-Pistofidis, Rohan Kodgule, …, Jesse M. Engreitz, Gad Getz, Luca Pinello, Russell J.H. Ryan, Irene M. Ghobrial

Cancer Research · 23 Sep 2024 · doi:10.1158/0008-5472.CAN-24-1440

A systematic review and meta-analysis of nonrelapse mortality after CAR T cell therapy

David M. Cordas dos Santos, Tobias Tix, Roni Shouval, Anat Gafter-Gvili, Jean-Baptiste Alberge, …, Michael von Bergwelt-Baildon, Irene M. Ghobrial, Marion Subklewe, Miguel-Angel Perales, Kai Rejeski

Nature Medicine · 08 Jul 2024 · doi:10.1038/s41591-024-03084-6

Mass spectrometry-detected MGUS is associated with obesity and other novel modifiable risk factors in a high-risk population

David J. Lee, Habib El-Khoury, Angela C. Tramontano, Jean-Baptiste Alberge, Jacqueline Perry, …, Stephen Harding, Lorelei Mucci, Timothy R. Rebbeck, Irene M. Ghobrial, Catherine R. Marinac

Blood Advances · 29 Mar 2024 · doi:10.1182/bloodadvances.2023010843

A p53 score derived from i TP53 i CRISPR Cas9 HMCLs predicts survival and reveals a major role of BAX in the response to BH3 mimetics

A p53 score derived from TP53 CRISPR/Cas9 HMCLs predicts survival and reveals a major role of BAX in the response to BH3 mimetics

Romane Durand, Géraldine Descamps, Céline Bellanger, Christelle Dousset, Sophie Maïga, …, Cyrille Touzeau, Philippe Moreau, David Chiron, Agnès Moreau-Aubry, Catherine Pellat-Deceunynck

Blood · 28 Mar 2024 · doi:10.1182/blood.2023021581

Integrated epigenetic and transcriptional single-cell analysis of t(11;14) multiple myeloma and its BCL2 dependency

Noémie Leblay, Sungwoo Ahn, Rémi Tilmont, Mansour Poorebrahim, Ranjan Maity, …, Arzina Jaffer, Benjamin G. Barwick, Lawrence H. Boise, Nizar Bahlis, Paola Neri

Blood · 04 Jan 2024 · doi:10.1182/blood.2023020276

2023

Mechanisms of antigen escape from BCMA- or GPRC5D-targeted immunotherapies in multiple myeloma

Holly Lee, Sungwoo Ahn, Ranjan Maity, Noemie Leblay, Bachisio Ziccheddu, …, Jonathan J. Keats, Leo Rasche, Francesco Maura, Paola Neri, Nizar J. Bahlis

Nature Medicine · 31 Aug 2023 · doi:10.1038/s41591-023-02491-5

Exploring the impact of dexamethasone on gene regulation in myeloma cells

Victor Bessonneau-Gaborit, Jonathan Cruard, Catherine Guerin-Charbonnel, Jennifer Derrien, Jean-Baptiste Alberge, …, Phillipe Moreau, Carl Herrmann, Jérémie Bourdon, Florence Magrangeas, Stéphane Minvielle

Life Science Alliance · 31 Jul 2023 · doi:10.26508/lsa.202302195

2022

MinimuMM-seq: Genome Sequencing of Circulating Tumor Cells for Minimally Invasive Molecular Characterization of Multiple Myeloma Pathology

Ankit K. Dutta, Jean-Baptiste Alberge, Elizabeth D. Lightbody, Cody J. Boehner, Andrew Dunford, …, Patricia T. Greipp, Chip Stewart, Daniel Auclair, Gad Getz, Irene M. Ghobrial

Cancer Discovery · 07 Dec 2022 · doi:10.1158/2159-8290.CD-22-0482

Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis

Rebecca Boiarsky, Nicholas J. Haradhvala, Jean-Baptiste Alberge, Romanos Sklavenitis-Pistofidis, Tarek H. Mouhieddine, …, Shankara K. Anand, François Aguet, David Sontag, Irene M. Ghobrial, Gad Getz

Nature Communications · 17 Nov 2022 · doi:10.1038/s41467-022-33944-z

Prevalence of monoclonal gammopathies and clinical outcomes in a high-risk US population screened by mass spectrometry: a multicentre cohort study

Habib El-Khoury, David J Lee, Jean-Baptiste Alberge, Robert Redd, Christian J Cea-Curry, …, Lorenzo Trippa, Timothy R Rebbeck, Gad Getz, Catherine R Marinac, Irene M Ghobrial

The Lancet Haematology · 01 May 2022 · doi:10.1016/S2352-3026(22)00069-2

Molecular Signature of sup 18 sup F-FDG PET Biomarkers in Newly Diagnosed Multiple Myeloma Patients: A Genome-Wide Transcriptome Analysis from the CASSIOPET Study

Molecular Signature of ¹⁸F-FDG PET Biomarkers in Newly Diagnosed Multiple Myeloma Patients: A Genome-Wide Transcriptome Analysis from the CASSIOPET Study

Jean-Baptiste Alberge, Françoise Kraeber-Bodéré, Bastien Jamet, Cyrille Touzeau, Hélène Caillon, …, Caroline Bodet-Milin, Michel Chérel, Philippe Moreau, Stéphane Minvielle, Clément Bailly

Journal of Nuclear Medicine · 27 Jan 2022 · doi:10.2967/jnumed.121.262884

Single-cell profiling of tumour evolution in multiple myeloma — opportunities for precision medicine

Ankit K. Dutta, Jean-Baptiste Alberge, Romanos Sklavenitis-Pistofidis, Elizabeth D. Lightbody, Gad Getz, Irene M. Ghobrial

Nature Reviews Clinical Oncology · 11 Jan 2022 · doi:10.1038/s41571-021-00593-y

2020

DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma

Jean-Baptiste Alberge, Florence Magrangeas, Mirko Wagner, Soline Denié, Catherine Guérin-Charbonnel, …, Hervé Avet-Loiseau, Thomas Carell, Philippe Moreau, Stéphane Minvielle, Aurélien A. Sérandour

Clinical Epigenetics · 02 Nov 2020 · doi:10.1186/s13148-020-00953-y